Abstract
The effect of carbon monoxide on brain oxidative metabolism was studied in 5 anesthetized newborn piglets during mechanical ventilation, at normoxic and normocarbic steady-state. Surface coil 31-Phosphorus (31-P) spectra (ATP, phosphocreatine (PCr), inorganic phosphoate (Pi), phosphomonoesters, and phosphodiesters), measured by NMR, were obtained every 4 min over a period of 2 hrs with a gradual increase of blood carboxyhemoglobin [COHb]. Measurements of blood gases, acidbase, and regional CBF were obtained at baseline, 30-40%, 50-60%, and 70-80% of blood [COHb] level, respectively. PCr/Pi decreased in all piglets from a mean of 1.65 to 0.5 in a linear relationship as a function of the gradual increase in [COHb] from 6.3 to 80.3%. CBF increased from 78 ml/min/lOOg to 172 to 220 parallel to increasing levels of [COHb] in all piglets. Oxygen delivery remained relatively unchanged from 466 umol/min/lOOg to 416 to 391, and decreased at [COHb] of 70-80% to 287 umol/min/100g. In contrast to previous data in our laboratory where PCr/Pi abruptly decreased when oxygen content reached 4%, PCr/Pi in the present studies remained relatively high for comparable decreased O2 content due to hypercarboxyhemoglobinemia, because blood flow remained relatively high in the presence of decreased oxygen content, whereas in hypoxic hypoxia flow was decreased at extreme hypoxemia. These data suggest that cerebral perfusion is better maintained in carbon monoxide than hypoxic hypoxia, possibly reflecting altered responsivity of brain vessels or adrenergic mechanisms capable of altering CBF as seen in hypoxic hypoxia.
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Delivoria-Papadopoulos, M., Wagerle, L., Goplerud, J. et al. 1374 CARBON MONOXIDE EFFECT ON BRAIN OXIDATIVE METABOLISM IN NEWBORN PIGLETS. Pediatr Res 19, 339 (1985). https://doi.org/10.1203/00006450-198504000-01398
Issue Date:
DOI: https://doi.org/10.1203/00006450-198504000-01398