Abstract
The effects of FPL57231 on plasma levels of 6-keto PGF1∝(6-keto) and TxB2, metabolites of PGI2 and thromboxane_A2, were examined during ventilation with 12% 02 in 5 piglets (x±SD; wt, 3194±1311g; age, 15±5d) treated with FPL57231 (2mg/kg × 10 min), and in 5 control piglets (C) (wt, 2958±1103g; age, 14±5d). Cardiac index, pulmonary artery (Ppa), systemic arterial, pulmonary wedge and right atrial pressures were measured; systemic and pulmonary vascular resistances (PVR) calculated. Levels of 6-keto and TxB2 were measured during normoxia (Norm BL), and after 20 (Hypoxic BL), 30, 35 and 55 min (') of hypoxia. FPL57231 was infused after hypoxic baseline measurements were made until 30'.
Ppa and PVR were lower (p<.05) in treatment animals during the study period. There was no significant difference between normoxic BL and 55' TxB2 or 6-keto levels in (C) animals. FPL-57231 was associated with an increase in TxB2 and 6-keto, suggesting that at this dose, FPL57231 may have lipoxygenase blocking activity. The decrease in PVR and Ppa in the presence of increased cyclcoxygenase products further supports the role of leukotrienes as possible mediators of HPH in piglets.
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Goldberg, R., Clark, M., Suguihara, C. et al. 367 EFFECTS OF A LEUKOTRIENE ANTAGONIST, FPL57231, ON THROMBOXANE B2 (TxB2) AND 6-KETO PGF1α LEVELS IN HYPOXIC PULMONARY HYPERTENSION (HPH) IN PIGLETS. Pediatr Res 19, 172 (1985). https://doi.org/10.1203/00006450-198504000-00397
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DOI: https://doi.org/10.1203/00006450-198504000-00397