Abstract
VIP relaxes cerebral vessels in vitro. Central nervous system (CNS) blood flow(BF) was measured (radioactive microspheres) in 6 - 8 week piglets during vehicle infusion and at 10 min of VIP (1 μg/kg/min, iv; plasma VIP of 9±2ng/ml). VIP increased heart rate (228±14 vs 136±8 beats/min, p<.001), reduced systemic pressure (64±5 vs 92±3mmHg, p<.001), while CO was unchanged (276±30 vs 261±20ml/min/kg). Caudate nucleus, cerebral gray and white matter BF was reduced by 19 to 25% while regional resistance was unchanged. In contrast, resistance was reduced by 23-34% in the spinal cord, brain stem and cerebellum while BF was unchanged.
Values are mean±SE; n=8; *p<0.02 to<0.005 vs Control
Thus, VIP induced CNS BF changes in awake piglets are different than in anesthetized animals. Whether this represents differential regional sensitivity to VIP or is a consequence of the systemic effects of VIP is unknown.
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Hohmann, E., Lorenz, E., Rysavy, J. et al. 377 EFFECT OF VASOACTIVE INTESTINAL PEPTIDE(VIP) ON CEREBRAL BLOOD FLOW IN THE AWAKE PIGLET. Pediatr Res 19, 173 (1985). https://doi.org/10.1203/00006450-198504000-00407
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DOI: https://doi.org/10.1203/00006450-198504000-00407