Abstract
Previous investigations of MCT in infants showed a high energetic utilization of the given substrate after single injection of 13C-MCT. To what extent these patients can oxidize MCT during continuous application, especially in comparison to LCT, is still uncertain. Therefore we measured with the 13CO2-breath test the oxidation of MCT and LCT in infants during continuous infusion of 13C-triglycerides. 9 infants, fed with supplementary parenteral nutrition, were investigated. The carbohydrate intake was 7.4-19.7 g/kg·24h. For investigation the parenterally applied fat emulsion was substituted by an isocaloric amount of the testemulsion either enriched with 13C-trioctanoin or 13C-triolein. The 13C-content, measured by mass-spectrometry, represents fatty acid oxidation. We found a higher MCT-oxidation compared with LCT: x=35.6±15.0% vs. x=18.6±8.3%. Both oxidation rates revealed a negative correlation to concomitant carbohydrate supply. The results show, that all patients can utilize parenterally applied MCT to a greater amount than LCT. MCT oxidation is also reduced by concomitant carbohydrate intake like LCT. On account of their high energetic utilization MCT in general are an adequate substrate for parenteral nutrition in infancy.
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Paust, H., Knoblach, G., Brösicke, H. et al. FATTY ACID OXIDATION IN ARTIFICIALLY FED INFANTS DURING CONTINUOUS INFUSION OF 13C-TRIOCTANOIN AND 13C-TRIOLEIN. Pediatr Res 22, 231 (1987). https://doi.org/10.1203/00006450-198708000-00109
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DOI: https://doi.org/10.1203/00006450-198708000-00109