Abstract
Neonatal septic shock from peritonitis is often fatal. To evaluate the efficacy of steroids in its resuscitation, anesthetized, neonatal pigs were subjected to fecal- E.coli peritonitis-induced septic shock by intraperitoneal inoculation. All animals received gentamicin and 5% albumin in lactated Ringer's solution at 10 cc/kg/hr. Metabolic acidosis was corrected as required, and ventilatory support was administered. Pigs were randomly divided into three groups. Group I, control animals, did not receive steroids. Groups II and III received methylprednisolone (30 mg/kg, IV) every 6 hours beginning when cardiac output dropped or one hour later, respectively. Microspheres were used to assess regional perfusion. Hemodynamics and regional blood flow were not significantly different by ANOVA. Pigs “survived” if hemodynamics were stable at 24 hrs, compared to baseline.
Steroids exert a beneficial influence on survival in this experimental neonatal shock model.
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Lobe, T., Gore, D., Mantor, C. et al. STEROIDS IMPROVE SURVIVAL IN EXPERIMENTAL NEONATAL SEPTIC SHOCK. Pediatr Res 21 (Suppl 4), 202 (1987). https://doi.org/10.1203/00006450-198704010-00217
Issue Date:
DOI: https://doi.org/10.1203/00006450-198704010-00217