Abstract
We evaluated GI motility by means of a perfused catheter system, DGR, as assessed by Bile Salts (BS) output in gastric aspirates, and GE of a milk labeled formula (% of emptying at 1 hr) in 11 patients (pts) with unexplained chronic vomiting. (Apts), in 8 pts with protracted gastroesophageal reflux (GER) disease (Bpts) and in 7 symptomatic controls (Cpts). Mean ± SD age (months) was respectively 44.2±37.7, 18.1±11.2, 20.4±14.4. In 9 Apts and 5 Bpts we found GI manometric abnormalities none of which were seen in Cpts: a) fasting and/or fed antral (and/or duodenal) hypomotility; b) abnormal propagation or configuration of interdigestive motor complexes (IMC); c) bursts of non propagated duodenal or jejunal motility; d) sustained fasting and/or fed phasic activity incoordinated with adjacent gut segments. Both A and B pts had BS fasting recovery significantly higher than Cpts during the various phases of IMC (mean group values (mg/ml): 1.52 (A), 1.12 (B), 0.36 (C), p < 0.05) and a significant delay of GE (A: 32.8±8.9%; B: 34.4±9.8%) as compared to Cpts (64.5±5.3%, p< 0.05, mean±SD). Highest degrees of gastric BS output and of delayed GE were associated with the most marked GI motility dysfunctions in both A and B pts. Conclusions: 1) children with chronic unexplained vomiting may exhibit, at GI manometry, disordered gut motility patterns; 2) the latter seem to be associated with increased DGR and delayed GE; 3) severe GER disease shows diffuse dysmotllity of upper GI tract.
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Cucchiara, S., Staiano, A., Colombo, C. et al. 24 GASTROINTESTINAL (GI) MOTILITY, DUODENOGASTRIC REFLUX (DGR) AND GASTRIC EMPTYING (GE) IN CHILDREN WITH CHRONIC VOMITING. Pediatr Res 24, 409 (1988). https://doi.org/10.1203/00006450-198809000-00047
Issue Date:
DOI: https://doi.org/10.1203/00006450-198809000-00047