Abstract
6 children (2 boys and 4 girls) with growth retardation (m = 2.8 ± 0.5 DS) were studied: mean chronological age was 11.9 ± 1.5 yr, mean bone age 9.3 ± 1.2 yr; they were all Tanner stage I for pubertal development; GH peak after 2 pharmacological tests were between 7 and 10 ng/ml, IC of GH was below 3 ng/ml/min. After an IV bolus of 1 ug/bw of GRF (1-29) NH2, mean maxurun GH peak was 30 ± 13 ng/ml ranging from 15 to 50 ng/ml. 24 hour GH secretion was studied before treatment and after one and 21 days of CSI of GRF. Traveml AS 8MP pumps were used, catheter and syringes were previously tested for GRF adhesion. The dose of GRF used was either 20 or 40 ug/bw/day. On day one, mean 24 hour IC of GH increased from 2.3 ± 0.4 to 5.7 ± 3.3 ng/ml/min, maxinun GH peak from 13 ± 4 to 35 t 20 ng/ml and the number of GH peaks above 5 ng/ml rose from 3.7 ± 0.8 to 6.8 ± 3.3. Among the 3 children (1 boy and 2 girls) receiving 20 ug/bw/day of GRF, only one increased his 24 hour IC of GH up to 3 ng/ml/min (from 2.31 to 4.74 ng/ml/min), but this result was obtained in the 3 children receiving 40 ug/bw/day. After 21 days of such treatment the mean value of 24 hour IC of GH was 5.2 ± 3.3 ng/ml/min, the mean maximm GH peak 28 ± 18 ng/ml and the mean number of GH peaks was 7.5 ± 2.9. In all but one child, the response to GRF (1-29) NH2 decreased whatever the dose used but the 24 hour IC of GH remained above 3 ng/ml/min when this value was obtained on day one. Local and general tolerance vas good.
In conclusion : the effect on 24 hour GH secretion after CSI of GRF (1-29) NH2 depend on the dose, normalization of 24 hour IC of GH was obtained in all cases when the dose was 40 ug/bw/day, this effect decreased after 21 days.
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Tauber, M., Pienkowski, C., Landier, F. et al. 95 ODIFICATION OF 24 HOUR GROWTH HORMONE (GH) SECRETION AFTER CONTINUOUS SUBCUTANEOUS INUECTION (CSI) OF GRF (1–29) NH2 DURING 3 WEEKS IN 6 CHILDREN WITH PARTIAL GH DEFICIENCY. Pediatr Res 24, 533 (1988). https://doi.org/10.1203/00006450-198810000-00116
Issue Date:
DOI: https://doi.org/10.1203/00006450-198810000-00116