Abstract
Human atrial natriuretic peptide (hANP) receptors have been identified in human placenta. HANP phosphorylates placental membrane proteins involving cyclic GMP-dependent protein kinase. -Because of this evidence for endocrine signalling via cGMP, does hANP have effects on carbohydrate metabolism in the human placenta?
Material and methods: Term placental tissue were incubated with 16.7 mmol/l glucose in medium 199 for 120 min. Alpha-hANP (Sigma) was added (50 and 100 pg/ml). Glucose utilization (UG), L-lactate production (PL) and the corresponding metabolic rates of free glucose by labelled substrate techniques were determined.
Results: 1. With 100 pg/ml hANP, the UG100 increased significantly (p < 0.006) to 31.6±4.3 % (mean ± SD) above controls reaching 6.3±1.6 umol/h/g (n=16). 2. UG50 was elevated to 19.7±10.4 % above controls (n=16). 3. The relative increment of PL referring the controls were 5.2 resp.11.1% (p < 0.03). 4. The UG and PL out of free glucose were dose dependently increased to 15.6±7.4 % resp. 16.2±7.8 %.
Conclusions: These results may reflect an elevated glucose turnover stimulated by hANP working as a vasoactive substance in the fetal placental vessels. - Supported by DFG (He 1107/2-3)
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Henrichs, I., Kellner, M., Benz, R. et al. 40 HUMAN ATRIAL NATRIURETIC PEPTIDE EXERTS ELEVATED GLUCOSE CONSUMPTION IN HUMAN PLACENTA. Pediatr Res 28, 283 (1990). https://doi.org/10.1203/00006450-199009000-00064
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DOI: https://doi.org/10.1203/00006450-199009000-00064