Abstract
ABSTRACT: To determine the relative importance of patent ductus arteriosus, indomethacin, and intestinal distension as factors that promote terminal ileum ischemia, eight near-term fetal lambs were surgically prepared by in situ cannulation of the proximal and distal ends of a loop of terminal ileum, formalin infiltration of the ductus arteriosus, and placement of a snare around the ductus arteriosus to control its patency. The incisions were closed; the lambs were delivered and mechanically ventilated. Terminal ileum blood flow and oxygen consumption were measured after the loop of ileum had been distended with 0.9% NaCl to luminal pressures of 1–2, 7, and 18 mm Hg (0.13–0.26, 0.93, and 2.38 kPa) (pressures observed in the intestinal lumen after feeding and during pathologic conditions). The effect of these pressures on terminal ileum blood flow and oxygen consumption was examined: 1) with ductus closed, 2) with ductus open, and 3) 1 h after administration of indomethacin (0.3 mg/kg; 0.8 μmol/kg) with ductus closed. Both open ductus and indomethacin produced a significant decrease in intestinal blood flow. This occurred over the entire range of luminal pressures examined. In all three study conditions, terminal ileum blood flow fell commensurate with a fall in perfusion pressure. Despite this absence of pressure-flow autoregulation, oxygen consumption was maintained when the ductus was closed or open. In contrast, indomethacin inhibited the ability of the terminal ileum to autoregulate its oxygen consumption. These findings suggest that both open ductus and indomethacin present an increased risk of intestinal ischemia. We hypothesize that indomethacin's beneficial effect on ductus closure may be counterbalanced by its negative effect on intestinal perfusion and metabolism.
Similar content being viewed by others
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Meyers, R., Emil Lln, G. & Clyman, R. Patent Ductus Arteriosus, Indomethacin, and Intestinal Distension: Effects on Intestinal Blood Flow and Oxygen Consumption. Pediatr Res 29, 564–574 (1991). https://doi.org/10.1203/00006450-199106010-00010
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1203/00006450-199106010-00010
This article is cited by
-
Serial Doppler velocimetry of mesenteric and portal flow in very-low-birth-weight preterm neonates with and without patent ductus arteriosus
Pediatric Radiology (2020)
-
Patent ductus arteriosus in premature infants: to treat or not to treat?
Journal of Perinatology (2017)
-
Outcomes of Primary Ligation of Patent Ductus Arteriosus Compared With Secondary Ligation After Pharmacologic Failure in Very-Low-Birth-Weight Infants
Pediatric Cardiology (2014)
-
Spectral Doppler waveforms in systemic arteries and physiological significance of a patent ductus arteriosus
Journal of Perinatology (2011)
-
Doppler manifestations of ductal steal: role in decision making
European Journal of Pediatrics (2011)