Abstract
Children with CRF are characterized by markedly short stature and Low bone mass. Thirteen prepobertal children with severe CRF(GFR<20.8 ml/min/1.73 m 2)and short stature (HSDS<3.6 below the mean)with a mean choronological age 6.7 ± 3.5yr. were studied using Dual X-ray Absorpsiometry before and after 6 months of treatment with rhGH (1 I.U. /Kg/Week) bone mass was measured in total body, lumbar spine (trabecular bone) and femoral neek (cortical bone). Total BMC was significantly lower in our patients compared to age matched healthy controls (443.2 ± 155.2 vs, 903.1 ± 369 g; p<0.003). After 6 months of rhGH treatment total BMC increased to 516.7 ± 147 g; p<0.05, in the group of CRF patients. Trabecular BMC increased from 0.496 ± 0.04 to 0.585 ± 0.1g/cm2 and cortical BMC increased from 0.605 ± 0.1 to 0.651 ± 0.08g/cm2 after 6 months of rhGH. Our findings indicate that children with CRF present with a low bone mass, and short term treatment with rhGH seems to increase their bone mineral content. Long term studies will be necessery to asses the real effect exerted by rhGH therapy on the skeleton of children with CRF as they increase their growth velocity.
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Gunezler, P., Lanes, R., Orta, N. et al. CHANGES IN BONE MINERAL, CONTENT (BMC) IN PREPUBERTAL, CHILDREN WITH MARKED SHORT STATHRE SECONDARY TO CHRONIC RENAL FAILURE (CRF): EFFECTS OF rhGH THERAPY. Pediatr Res 33 (Suppl 5), S43 (1993). https://doi.org/10.1203/00006450-199305001-00239
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DOI: https://doi.org/10.1203/00006450-199305001-00239