Abstract
With birth circulatory and respiratory changes ensue leading to fetal oxidative stress evidenced by changes in the glutathione status. Pregnant rats receiving NAC during gestation were sacrificed at 21±1d. Fetuses delivered by c-section and immediately sacrificed anc newborns at 24h age. Livers were processed(l) and GSH and GSSG determined.
We conclude that oxidative stress associated with birth in rat fetuses might be partially prevented by NAC given to the mother during gestation.
(1) Viña J et al; Biochem J 170; 627-630 (1978)
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Vento, M., Garcia-Sala, F., Catalá, J. et al. 238 ANTIOXIDANT ADMINISTRATION TO THE MOTHER PREVENTS OXIDATIVE STRESS ASSOCIATED WITH BIRTH IN THE NEONATAl RAT. Pediatr Res 36, 42 (1994). https://doi.org/10.1203/00006450-199407000-00238
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DOI: https://doi.org/10.1203/00006450-199407000-00238