Abstract
Height and growth were evaluated in 31 children of both sexes after Tx:16 clinically prepubertal (PP) with a mean(X±SD) chronological age(CA) of 11.5±4.16 years (y) and a bone age (BA) of 6.91 ±2.17y, and 15 pubertal (P), Tanner's stages 2-4, with a CA of 16.4± 2.46 and a BA of 13.6±1.65 y. Height SD score(S) was -3.73 ±1.48 in PP and -3.54±1.66 in P. Height SDS was correlated with time of pre-Tx CRF (PP:6.06±4.19 and P: 6.99±4.05y), Post-Tx CRF (PP:2.28±1.59 and P: 2.15±1.67 y) and creatinine clearance (CrCl) (PP: 67.3±36.8 and 71.4±30.7 ml/min.1.73). An iverse significative correlation was found between height SDS and time of Pre-Tx CRF in PP(r:-0.50, p<0.05), but not in P, and between height SDS and time of Post-Tx GRF in PP and P(r:-0.61, p<0.02 and r: -0.52, p<0.02, respectively), and a direct one between height SDS and CrCl in PP and P (r: 0.71, p<0.01 and r: 0.54, p<0.02, respectively). Furthermore, in the 31 patients, CrCl was correlated with growth velocity and time post-Tx. It was found that the r had a direct significant correlation with growth velocity SDS(r:0.62, p<0.01) and an inverse correlation with time post-Tx (r:-0.41, p<0.02). There was no significatn correlation between dose of methyl prednisolone during the last 6-12 months (mean dose: 4.95±1.39 mg/m2 body surgace area) and growth velocity SDS. It is concluded that growth is one of most sensitive parameters of post-Tx altered renal function. Reduced CrCl is an important indicator in growth failure of children before and during puberty.
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Castellano, M., Turconi, A., Rivarola, M. et al. 31 HEIGHT AND GROWTH VELOCITY IN CHILDREN WITH CHRONIC RENAL FAILURE (CRF) AFTER RENAL TRANSPLANTATION (Tx). Pediatr Res 36, 677 (1994). https://doi.org/10.1203/00006450-199411000-00055
Issue Date:
DOI: https://doi.org/10.1203/00006450-199411000-00055