Abstract
Little is known about the changes in the secretion patterns of the major fluid and electrolyte regulatory hormones following severe thermal injury in children. Resuscitation protocols are based mainly on data derived from studies in adults. The aim of our study was to investigate the changes in secretion of the major fluid controlling (actors, vasopressin, (AVP), atrial natriuretic peptide (ANP), angiotensin (All), plasma renin (PRA), aldosterone (ALD) and the catecholamines ( NOR, ADR, DA) in children with severe burn injuries.
Methods: 7 children, 0.6 - 4.8 yr (median 1.9 yr) admitted to the Plastic Surgical Unit of the Royal Hospital for Sick Children, Edinburgh, with severe thermal injuries, 12 - 61 %body surface area (median 21%), were evaluated over the first 4 days following injury. An extra 1.5ml of blood for hormone determinations was obtained whenever a sample was taken for clinical evaluations.
Results: As data was not normally distributed, geometric mean hormone levels were calculated. Values are given in pg/ml (peptides), pmol/mlhr (PRA) and pmol/ml (CATS)
Conclusions: We believe that these are the first reported data showing secretion profiles of the major fluid and electrolyte regulating factors in burn injured children.
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Smith, A., Ritchio, M., Stephon, R. et al. SECRETION PROFILES OF THE MAJOR FLUID AND ELECTROLYTE REGULATORY HORMONES FOLLOWING SEVERE THERMAL INJURY. Pediatr Res 35, 264 (1994). https://doi.org/10.1203/00006450-199402000-00058
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DOI: https://doi.org/10.1203/00006450-199402000-00058