Abstract
There was a known relationship between cumulative postnatal energy deficit and extra uterine growth restriction experienced by VLBW infants.
Objectives: To determine whether reduction of nutritional deficit had an effect on postnatal growth of ELBW infants born below 28 weeks.
Method: Comparison of postnatal growth between 2 cohorts cared for before (2005) and after (2009) implementation (2006) of a nutrition program that significantly reduced deficit.
Delta z-scores for weight, length and head circumference were calculated each week as the z-scores difference between birth and 36 weeks PMA. Results are reported as median (Q1, Q3). Mann-Whitney test were performed for each criteria.
Results: We compared 33 ELBW infants who experienced nutritional deficit to 32 not exposed to this undernutrition. There was no difference for GA (p=0.28) and BW (p=0.11).
There was a significant reduction of delta z-score for length (- 1.49 (-1.93, -0.97) -0.89 (-1.76, -0.17), p=0.012). Delta z-score was neither significantly reduced for weight (- 0.19 (-0.79, +0.11) -0.03 (-0.46, +0.55), p=0.09), nor head circumference (- 0.83 (-1.26, -0.23) -0.79 (-1.47, -0.06), p=0.83).
Discussion: This nutrition program allowed reduction of lean mass growth restriction.
Conclusion: Independent effects of energy and protein have to be determined into a multivariate model that also includes non nutritional parameters.
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Loÿs, CM., Maucort-Boulch, D., Guy, B. et al. 1069 Reduction of Nutritional Deficit Minimize Extra Uterine Growth Restriction Among Extremely Low Birth Weight Infants. Pediatr Res 68 (Suppl 1), 531 (2010). https://doi.org/10.1203/00006450-201011001-01069
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DOI: https://doi.org/10.1203/00006450-201011001-01069