Abstract
The prevalence of overweight in adolescents and children in Europe is about 20%. Comparing to general population survivors of pediatric acute lymphoblastic leukemia (ALL) have increased risk of being overweight. The purpose of the study was determination of leptin and leptin soluble receptor in ALL survivors. 82 patients (male 55%), aged 5 to 26 (median 13) years were studied. ALL therapy was conducted according to modified German (n=69) or American (n=13) regimens. In 38% cranial radiotherapy (CRT) was used in median dose 18.2Gy. Median age at diagnosis and time from completion of treatment were 5 and 3 years respectively. Patients with BMI ≥85 percentile were classified as overweight. Correlation of plasma concentration of leptin and leptin soluble receptor, and overweight was analyzed with respect to the intensity of chemotherapy and to CRT. Overweight was observed in 31% of studied group. There was a significant increase in leptin concentrations in entire overweight, overweight girls and radiotherapy subgroups. Reverse relationship was observed for soluble leptin receptor concentrations with significant differences in entire overweight group as well as in overweight boys. There were significant negative correlations (p< 0.05) between leptin and leptin receptor in the entire group and in gender subgroups.
Conclusions:
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1) The prevalence of obesity in our cohort was higher than in European population (31% vs 20%),
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2) leptin and leptin receptor levels can serve as good markers for high risk of overweight specially for patients treated with cranial radiotherapy.
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Skoczen, S., Tomasik, P., Surmiak, M. et al. 1114 Plasma Levels of Leptin and Soluble Leptin Receptor in Survivors of Childhood Acute Lymphoblastic Leukemia. Pediatr Res 68 (Suppl 1), 552 (2010). https://doi.org/10.1203/00006450-201011001-01114
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DOI: https://doi.org/10.1203/00006450-201011001-01114