Abstract
Background & aims: Lately several assisted reproductive technologies (ART) had been develped. while a lot of development, the structural defects and the relationship between congenital anomalies of infants conceived through ART are being actively studied. Among them, the relationship of development of cardiac defects between ART are rarely reported. This study investigated differences in neonatal septal heart defects and patent ductus arteriosus between ART and unassisted conception.
Methods: During 2005-2009, Among 9,836 newborns delivered, number of infants conceived by ART was 954 cases, 8,880 cases of unassisted conceived infants. In each group, ASD, VSD, PDA by echocardiogram before 3 months of age were diagnosed. And also chromosomal defect, other malformations were reviewed. Perinatal characteristics (gestational age, maternal age, birth weight, sex, multiple or single) were reviewed.
Results: The results of comparison ART group with unassisted conception group revealed gestational age (35+6± 2+5 Week vs. 37+6± 2+3 Weeks) and birth weight(2,470 ± 620 g vs. 3,060 ± 590 g), multiple frequency rate (68.2% vs. 6.4%). And also the incidence of ASD (0.5% vs. 0.3%, P= 0.197)and VSD (0.5% vs. 0.3%, P= 0.323) between groups did not differ, but incidence of PDA (4.6% vs. 1.8%, P< 0.0001)of ART group was higher. Heart disease incidence was unrelated to multiple pregnancy (P= 0.743).
Conclusions: The incidence of ASD an VSD was not different between the ART group and unassisted conceived group. And the incidence of PDA was higher in ART group. However, considering the relating factors, ART was not related to the development of PDA.
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Lee, K. 633 Septal Defect and Patent Ductus Arteriosusafter Assisted Reproductive Technology. Pediatr Res 68 (Suppl 1), 324 (2010). https://doi.org/10.1203/00006450-201011001-00633
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DOI: https://doi.org/10.1203/00006450-201011001-00633