Table 1 Characteristics of the patients
Variable | Patients without cholestasis | Patients with cholestasis | p valuea |
---|---|---|---|
Patients (n) | 26 | 20 | 0.25 |
Short bowel syndrome (n) | 6 | 9 | 0.59 |
Male (n) | 16 | 11 | 0.69 |
Age (months) | 5 (3.3–6) | 5 (3.1–7) | 0.87 |
Gestational age (weeks) | 37 (31.5–38) | 36 (30–39) | 0.58 |
Gestational weight (g) | 2900 (1486–3162) | 2650 (2030–3025) | 0.08 |
Plasma alkaline phosphatase, ALP (U/L) | 240.5 (201.5–286.5) | 275 (173–311.6) | <0.01 |
Plasma alanine aminotransferase, ALT (U/L) | 45 (31.5–89) | 56 (33.6–97) | <0.01 |
Plasma aspartate aminotransferase, AST (U/L) | 59 (47.9–98.7) | 67 (56.5–114.5) | <0.01 |
Plasma total bilirubin (μmol/L) | 9.7 (9.2–18.5) | 13.5 (9.5–34.2) | 0.01 |
Plasma conjugated bilirubin (μmol/L) | 2.3 (0.2–5.2) | 10.5 (9.3–22.5) | 0.03 |
Serum IL-6 (pg/mL) | 4.2 (4.6–7.8) | 7.7 (4.3–41.5) | <0.01 |
Serum TNF-α (pg/mL) | 6.9 (0.7–14.7) | 8.6 (7.3–15.4) | <0.01 |