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Maximum home blood pressure readings are associated with left atrial diameter in essential hypertensives

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Abstract

We tested the hypothesis that the maximum value of home systolic BP (MSBP) is a marker of hypertensive target organ damage (TOD). We conducted a cross-sectional study of 220 hypertensives. The subjects performed HBP monitoring using a telemonitoring system and measured their HBP for 7 days. Mean, maximum, standard deviation, and coefficient of variation of SBPs were used as independent variables. Brachial–ankle pulse wave velocity, left ventricular mass index (LVMI), mean carotid intima–media thickness, and left atrial diameter index (LADI) were used as dependent variables. Mean and maximum SBPs were significantly associated with each TOD marker. MSBP showed a significantly stronger association with LADI compared to mean SBP (p = 0.0012) and a significant relationship with LADI independent of LVMI (p = 0.024). Our findings suggest that MSBP is associated with TOD measures, similar to mean SBP. These results may indicate that MSBP could be a target of intervention for patients with atrial fibrillation.

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References

  1. Bobrie G, Chatellier G, Genes N, Clerson P, Vaur L, Vaisse B, et al. Cardiovascular prognosis of “masked hypertension” detected by blood pressure self-measurement in elderly treated hypertensive patients. JAMA. 2004;291:1342–9.

    Article  PubMed  CAS  Google Scholar 

  2. Imai Y, Ohkubo T, Hozawa A, Tsuji I, Matsubara M, Araki T, et al. Usefulness of home blood pressure measurements in assessing the effect of treatment in a single-blind placebo-controlled open trial. J Hypertens. 2001;19:179–85.

    Article  PubMed  CAS  Google Scholar 

  3. Mengden T, Hernandez Medina RM, Beltran B, Alvarez E, Kraft K, Vetter H. Reliability of reporting self-measured blood pressure values by hypertensive patients. Am J Hypertens. 1998;11:1413–7.

    Article  PubMed  CAS  Google Scholar 

  4. Kaihara T, Eguchi K, Kario K. Home BP monitoring using a telemonitoring system is effective for controlling BP in a remote island in Japan. J Clin Hypertens. 2014;16:814–9.

    Article  Google Scholar 

  5. Kikuya M, Ohkubo T, Metoki H, Asayama K, Hara A, Obara T, et al. Day-by-day variability of blood pressure and heart rate at home as a novel predictor of prognosis: the Ohasama study. Hypertension. 2008;52:1045–50.

    Article  PubMed  CAS  Google Scholar 

  6. Hansen TW, Thijs L, Li Y, Boggia J, Kikuya M, Björklund-Bodegård K, et al. International database on ambulatory blood pressure in relation to cardiovascular outcomes investigators. Prognostic value of reading-to-reading blood pressure variability over 24h in 8938 subjects from 11 populations. Hypertension. 2010;55:1049–57.

    Article  PubMed  CAS  Google Scholar 

  7. Rothwell PM, Howard SC, Dolan E, O’Brien E, Dobson JE, Dahlöf B, et al. Prognostic significance of visit-to-visit variability, maximum systolic blood pressure, and episodic hypertension. Lancet. 2010;375:895–905.

    Article  PubMed  Google Scholar 

  8. Dolan E, O’Brien E. Blood pressure variability: clarity for clinical practice. Hypertension. 2010;56:179–81.

    Article  PubMed  CAS  Google Scholar 

  9. Matsui Y, Ishikawa J, Eguchi K, Shibasaki S, Shimada K, Kario K. Maximum value of home blood pressure: a novel indicator of target organ damage in hypertension. Hypertension. 2011;57:1087–93.

    Article  PubMed  CAS  Google Scholar 

  10. Fukui M, Ushigome E, Tanaka M, Hamaguchi M, Tanaka T, Atsuta H, et al. Home blood pressure variability on one occasion is a novel factor associated with arterial stiffness in patients with type 2 diabetes. Hypertens Res. 2013;36:219–25.

    Article  PubMed  CAS  Google Scholar 

  11. Johansson JK, Niiranen TJ, Puukka PJ, Jula AM. Prognostic value of the variability in home-measured blood pressure and heart rate: the Finn-Home study. Hypertension. 2012;59:212–8.

    Article  PubMed  CAS  Google Scholar 

  12. Lee SE, Youn JC, Lee HS, Park S, Lee SH, Cho IJ, et al. Left atrial volume index is an independent predictor of hypertensive response to exercise in patients with hypertension. Hypertens Res. 2015;38:137–42.

    Article  PubMed  Google Scholar 

  13. Su G, Cao H, Xu S, Lu Y, Shuai X, Sun Y, et al. Left atrial enlargement in the early stage of hypertensive heart disease: a common but ignored condition. J Clin Hypertens. 2014;16:192–7.

    Article  Google Scholar 

  14. Appleton CP, Galloway JM, Gonzalez MS, Gaballa M, Basnight MA. Estimation of left ventricular filling pressures using two-dimensional and Doppler echocardiography in adult patients with cardiac disease. Additional value of analyzing left atrial size, left atrial ejection fraction and the difference in duration of pulmonary venous and mitral flow velocity at atrial contraction. J Am Coll Cardiol. 1993;22:1972–82.

    Article  PubMed  CAS  Google Scholar 

  15. McManus DD, Xanthakis V, Sullivan LM, Zachariah J, Aragam J, Larson MG, et al. Longitudinal tracking of left atrial diameter over the adult life course: clinical correlates in the community. Circulation. 2010;121:667–74.

    Article  PubMed  PubMed Central  Google Scholar 

  16. Cipollini F, Arcangeli E, Seghieri G. Left atrial dimension is related to blood pressure variability in newly diagnosed untreated hypertensive patients. Hypertens Res. 2016;39:583–7.

    Article  PubMed  Google Scholar 

  17. dabl® Educational Trust. Devices for blood pressure measurement. http://www.dableducational.com. Accessed July 2017.

  18. Imai Y, Otsuka K, Kawano Y, Shimada K, Hayashi H, Tochikubo O, et al. Japanese Society of Hypertension (JSH) Guidelines for Self-monitoring of Blood Pressure at Home. Hypertens Res. 2003;26:771–82.

    Article  PubMed  Google Scholar 

  19. Lang RM, Badano LP, Mor-Avi V, Afilalo J, Armstrong A, Ernande L, et al. Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. J Am Soc Echocardiogr. 2015;28:1–39.

    Article  PubMed  Google Scholar 

  20. Ferrara LA, Vaccaro O, Cardoni O, Laurenzi M, Mancini M, Zanchetti A. Indexation criteria of ventricular mass and predictive role of blood pressure and body composition. Am J Hypertens. 2005;18:1282–7.

    Article  PubMed  Google Scholar 

  21. Pritchett AM, Jacobsen SJ, Mahoney DW, et al. Left atrial volume as an index of left atrial size: a population-based study. J Am Coll Cardiol. 2003;41:1036–43.

    Article  PubMed  Google Scholar 

  22. Tomiyama H, Matsumoto C, Shiina K, Yamashina A. Brachial-ankle PWV: current status and future directions as a useful marker in the management of cardiovascular disease and/or cardiovascular risk factors. J Atheroscler Thromb. 2016;23:128–46.

    Article  PubMed  CAS  Google Scholar 

  23. Ohkuma T, Ninomiya T, Tomiyama H, Kario K, Hoshide S, Kita Y, et al. Brachial-ankle pulse wave velocity and the risk prediction of cardiovascular disease: an individual participant data meta-analysis. Hypertension. 2017;69:1045–52.

    Article  PubMed  CAS  Google Scholar 

  24. Takashima N, Turin TC, Matsui K, Rumana N, Nakamura Y, Kadota A, et al. The relationship of brachial-ankle pulse wave velocity to future cardiovascular disease events in the general Japanese population: the Takashima Study. J Hum Hypertens. 2014;28:323–7.

    Article  PubMed  CAS  Google Scholar 

  25. The Joint Committee of the Japan Academy of Neurosonology and the Japan Society of Embolus Detection and Treatment on Guideline for Neurosonology. Carotid Ultrasound Examination. Neurosonology 2006;19:49–67.

  26. Hoshide S, Yano Y, Shimizu M, Eguchi K, Ishikawa J, Kario K. Is home blood pressure variability itself an interventional target beyond lowering mean home blood pressure during anti-hypertensive treatment? Hypertens Res. 2012;35:862–6.

    Article  PubMed  CAS  Google Scholar 

  27. Tadic M, Cuspidi C, Ilic I, Suzic-Lazić J, Zivanovic V, Jozika L, et al. The relationship between blood pressure variability, obesity and left atrial phasic function in hypertensive population. Int J Cardiovasc Imaging. 2016;32:603–12.

    Article  PubMed  Google Scholar 

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Acknowledgements

We gratefully acknowledge Ms. Matsumoto, Ms. Okura, and Ms. Ochiai for their coordination and data management of this study and editorial assistance.

Funding

This work was supported by the Japanese Study Group for the Physiology and Management of Blood Pressure by Omron Healthcare Co., Ltd.

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Correspondence to Toshiki Kaihara.

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The authors declare that they have no conflict of interest.

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Kaihara, T., Imaizumi, Y., Eguchi, K. et al. Maximum home blood pressure readings are associated with left atrial diameter in essential hypertensives. J Hum Hypertens 32, 432–439 (2018). https://doi.org/10.1038/s41371-018-0060-3

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