Abstract
This study was performed to investigate the association between stage 1 hypertension defined by the 2017 ACC/AHA guidelines and the risk of adverse events among adults aged 35 to 49 years. A total of 20,072 adults aged 35–49 years, without a history of cardiovascular disease (CVD) at baseline were included in the present study. Adjusted Cox proportional hazards models were applied to estimate hazard ratios (HRs) with 95% confidence intervals (CIs). During a median follow-up period of 12.5 years, the results indicated that 777 subjects suffered all-cause death and 299 subjects developed CVD. A total of 830 subjects were involved in incident stroke and 141 subjects had a myocardial infarction (MI). Stage 1 hypertension had a HR (95% CI) of 1.38 (1.13–1.70) for all-cause mortality, 1.74 (1.20–2.53) for CVD mortality, 1.78 for (1.40–2.26) for stroke incidence, and 1.64 (0.99–2.71) for MI incidence, respectively, compared with blood pressure (BP) <120/<80 mmHg. The results show that after adjusting for sex, age, and other potential CVD factors, the incidence of stroke was the only parameter significantly associated with stage 1 hypertension (HR and 95% CI: 1.53, 1.20–1.95). Stage 1 hypertension defined by the 2017 ACC/AHA guidelines was associated with an increased risk of stroke among adults aged 35 to 49 years in rural areas of China.
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Change history
19 September 2019
A Correction to this paper has been published: https://doi.org/10.1038/s41371-019-0251-6
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Acknowledgements
All of the investigators and staff members were gratefully acknowledged. Thanks for all the enthusiastic participants.
Funding
This research was partly supported by funds from National Nature Science Foundation of China (No. 81773510), Nature Science Foundation of Liaoning Province (No. 20170541048), National Key R&D Program of China (Grant #2017YFC1307600), and National Key R&D Program of China (Grant #2018YFC1311600).
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Liu, S., Wang, Y., Xie, Y. et al. The association of stage 1 hypertension defined by the 2017 ACC/AHA hypertension guideline and subsequent cardiovascular events among adults <50 years. J Hum Hypertens 34, 233–240 (2020). https://doi.org/10.1038/s41371-019-0242-7
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DOI: https://doi.org/10.1038/s41371-019-0242-7
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