Abstract
Background
We performed a case-control study to characterise infants with “prolonged transitional hypoglycaemia”.
Methods
Cases were born ≥36 weeks’ gestation; had ≥1 hypoglycaemic episode <72 h and ≥72 h; received ongoing treatment for hypoglycaemia ≥72 h; and were without congenital disorders or acute illness. Cases were compared to controls born ≥36 weeks’ with brief transitional hypoglycaemia, resolving <72 h.
Results
39/471 infants screened met case definition: 71.8% were male, 61.5% were small-for-gestational-age (SGA), and most were admitted <6 h. Compared to controls (N = 75), key risk factors for prolonged transitional hypoglycaemia were SGA (OR = 6.4, 95%CI 2.7–15.1), severe/recurrent hypoglycaemia <24 h (OR = 16.7, 95%CI 4.5–16.1), intravenous glucose bolus <24 h (OR = 26.6, 95%CI 9.4–75.1) and maximum glucose delivery rate <48 h of ≥8 mg/kg/min (OR = 25.5, 95%CI 7.7–84.1).
Conclusions
Infants with prolonged transitional hypoglycaemia are predominantly male, SGA and have early severe/recurrent hypoglycaemia requiring glucose boluses and high glucose delivery rates in the first 24–48 h.
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Data availability
Published data are available to approved researchers under the data sharing arrangements provided by the Clinical Data Research Hub (CCRH), based at the Liggins Institute, University of Auckland (https://wiki.auckland.ac.nz/researchhub). Metadata, along with instructions for data access, are available at the University of Auckland’s research data repository, Figshare (https://auckland.figshare.com). Data access requests are to be submitted to Data Access Committee via researchhub@auckland.ac.nz. De-identified published data will be shared with researchers who provide a methodologically sound proposal and have appropriate ethical and institutional approval. Researchers must sign and adhere to the Data Access Agreement that includes a commitment to using the data only for the specified proposal, to refrain from any attempt to identify individual participants, to store data securely and to destroy or return the data after completion of the project. The CDRH reserves the right to charge a fee to cover the costs of making data available, if required.
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Acknowledgements
Lisa Mravicich is a non-author contributor; she assisted with chart review and data entry (Liggins Institute, University of Auckland and Kidz First, Counties Manukau Health, Auckland, New Zealand). We thank the pre-hPOD Trial Steering Group for providing control data (Jane M Alsweiler, Caroline A Crowther, Richard Edlin, Greg D Gamble, Jane E Harding).
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This study was unfunded.
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Bailey, M.J., Rout, A., Harding, J.E. et al. Prolonged transitional neonatal hypoglycaemia: characterisation of a clinical syndrome. J Perinatol 41, 1149–1157 (2021). https://doi.org/10.1038/s41372-020-00891-w
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DOI: https://doi.org/10.1038/s41372-020-00891-w
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