Summary
Phosphatases of regenerating liver (PRL1–3) are among the most oncogenic protein phosphatases but their mechanism of action is poorly understood. Multiple substrates have been proposed as well as a non-catalytic function regulating magnesium transport. Our recent identification of a catalytically inactive PRL mutant that retains oncogenicity in a mouse model promises to resolve the question of whether PRLs act as phosphatases or pseudo-phosphatases in different cancer models.
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Change history
10 March 2021
A Correction to this paper has been published: https://doi.org/10.1038/s41416-021-01311-2
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K.G. and H.M. contributed to the writing, revision, and approval of this manuscript.
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This work was supported by the Natural Sciences and Engineering Research Council of Canada.
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Gehring, K., Miki, H. Phosphatase, pseudo-phosphatase, or both? Understanding PRL oncogenicity. Br J Cancer 124, 1035–1036 (2021). https://doi.org/10.1038/s41416-020-01194-9
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DOI: https://doi.org/10.1038/s41416-020-01194-9