Abstract
LC/MS-based chemical screening of culture extract led to a new highly oxygenated angucycline derivative, grecocycline D (1), from Streptomyces sp. KCB15JA014, isolated from a soil sample of Oedolgae in Jeju Island, Korea. The planar structure was determined on the basis of spectroscopic analysis, including 1D and 2D NMR techniques as well as HRESIMS and comparison with data from the literature. A relative and absolute configuration of 1 was assigned by ROESY experiment and electronic circular dichroism calculation. Compound 1 showed weak inhibitory activity against indoleamine 2,3-dioxygenase.
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Acknowledgements
This work was supported by a National Research Council of Science & Technology (NST) grant (ASIA-16-001 and CAP-16-03-KRIBB) and the KRIBB Research Initiative Program funded by the Ministry of Science ICT (MSIT) of the Republic of Korea. We thank the Korea Basic Science Institute, Ochang, Korea, for providing the NMR (700 and 900 MHz), HRESIMS, and CD data.
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Kim, G.S., Kim, G.J., Lee, B. et al. Highly oxygenated angucycline from Streptomyces sp. KCB15JA014. J Antibiot 73, 859–862 (2020). https://doi.org/10.1038/s41429-020-0348-8
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DOI: https://doi.org/10.1038/s41429-020-0348-8