Abstract
The score based on the office systolic blood pressure, age, fasting blood glucose level, and estimated glomerular filtration rate (SAGE score) has been proposed as a useful marker to identify elevated values of carotid-femoral pulse wave velocity (PWV). The present cross-sectional study was conducted to examine whether the SAGE score is also a useful marker to identify subjects with elevated brachial-ankle PWV values in Japanese subjects with hypertension. We measured the brachial-ankle PWV and calculated the SAGE score in a total of 1019 employees of a Japanese company with hypertension and 817 subjects with hypertension derived from a multicenter study cohort. The analyses in this study were based on data from these two study groups as well as on a composite population of the two (n = 1836). The receiver operating characteristic curve analysis showed that the area under the curve to identify subjects with brachial-ankle PWV values of ≥1800 cm/s was over 0.70 in each of the three study groups. Even after adjustments, a SAGE score ≥7 had a significant odds ratio for identifying subjects with brachial-ankle PWV values ≥1800 cm/s in the 1836 study subjects from the composite occupational and multicenter study cohort (odds ratio = 2.1, 95% confidence interval = 1.4–3.0, P < 0.01). Thus, in Japanese subjects with hypertension, the SAGE score may be a useful marker for identifying subjects with elevated brachial-ankle PWV values.
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Funding
This study was partially supported financially by a Grant-in-Aid for scientific research from the Ministry of Health, Labour and Welfare, by the Japanese Atherosclerosis Prevention Research Fund (A study of Multi-center Assessment on the Clinical Usefulness of Semi-automatic Measurement of Flow-mediated Vasodilatation of the Brachial Artery: FMD-J study), and by the Omron Health Care Company, Kyoto, Japan.
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The sponsor (Omron Health Care Company) assisted in the data formatting (i.e., the brachial-ankle pulse wave velocity data stored in the hard disc of the equipment used for measurement of the brachial-ankle pulse wave velocity was transferred to an Excel file); other than this, the company played no role in the design or conduct of the study, i.e., in the data collection, management, analysis or interpretation of the data, or in the preparation, review or approval of the manuscript.
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Tomiyama, H., Vlachopoulos, C., Xaplanteris, P. et al. Usefulness of the SAGE score to predict elevated values of brachial-ankle pulse wave velocity in Japanese subjects with hypertension. Hypertens Res 43, 1284–1292 (2020). https://doi.org/10.1038/s41440-020-0472-7
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DOI: https://doi.org/10.1038/s41440-020-0472-7