Synthetic mammalian cells engineered to synthesize a painkiller in response to volatile spearmint reduce chronic pain in mice and do not seem to elicit adverse effects.
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References
Volkow, N. D. & McLellan, A. T. N. Engl. J. Med. 374, 1253–1263 (2016).
Ji, R. R., Xu, Z. Z. & Gao, Y. J. Nat. Rev. Drug. Discov. 13, 533–548 (2014).
Dib-Hajj, S. D., Yang, Y., Black, J. A. & Waxman, S. G. Nat. Rev. Neurosci. 14, 49–62 (2013).
Peng, K., Shu, Q., Liu, Z. & Liang, S. J. Biol. Chem. 277, 47564–47571 (2002).
Wang, H., Xie, M., Charpin-El Hamri, G., Ye, H. & Fussenegger, M. Nat. Biomed. Eng. https://doi.org/10.1038/s41551-018-0192-3 (2018).
Xie, M., Haellman, V. & Fussenegger, M. Curr. Opin. Biotechnol. 40, 139–148 (2016).
Weber, W. & Fussenegger, M. Nat. Rev. Genet. 13, 21–35 (2011).
Villarreal, F. et al. Nat. Chem. Biol. 14, 29–35 (2018).
Gootenberg, J. S. et al. Science 356, 438–442 (2017).
Chen, Z. et al. Nat. Chem. Biol. 14, 86–93 (2018).
Roybal, K. T. et al. Cell 164, 770–779 (2016).
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Lewis, D.D., Tan, C. Aroma-triggered pain relief. Nat Biomed Eng 2, 58–59 (2018). https://doi.org/10.1038/s41551-018-0197-y
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DOI: https://doi.org/10.1038/s41551-018-0197-y