Targeting antigens to the liver by glycosylation promotes antigen-specific immune tolerance via the expansion of regulatory T cells and prevents autoimmunity in a mouse model of type-1 diabetes.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 digital issues and online access to articles
$99.00 per year
only $8.25 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Rosenblum, M. D., Gratz, I. K., Paw, J. S. & Abbas, A. K. Sci. Transl. Med. 4, 125sr1 (2012).
Tiegs, G. & Lohse, A. W. J. Autoimmun. 34, 1–6 (2010).
Doherty, D. G. J. Autoimmun. 66, 60–75 (2016).
Crispe, I. N. J. Hepatol. 54, 357–365 (2011).
Horst, A. K., Neumann, K., Diehl, L. & Tiegs, G. Cell. Mol. Immunol. 13, 277–292 (2016).
Karimi, M. H., Geramizadeh, B. & Malek-Hosseini, S. A. Int. J. Organ Transpl. Med. 6, 45–54 (2015).
Breous, E., Somanathan, S., Vandenberghe, L. H. & Wilson, J. M. Hepatology 50, 612–621 (2009).
Chen, W. et al. J. Exp. Med. 198, 1875–1886 (2003).
Josefowicz, S. Z., Lu, L. F. & Rudensky, A. Y. Annu. Rev. Immunol. 30, 531–564 (2012).
Carambia, A. et al. J. Hepatol. 61, 594–599 (2014).
Sharabi, A. et al. Nat. Rev. Drug. Discov. 17, 823–844 (2018).
Bluestone, J. A. & Tang, Q. Science 362, 154–155 (2018).
Wilson, D. S. et al. Nat. Biomed. Eng. https://doi.org/10.1038/s41551-019-0424-1 (2019).
Maynard, Y. & Baenziger, J. U. J. Biol. Chem. 257, 3788–3794 (1982).
Bilyy, R. & Stoika, R. Autoimmunity 40, 249–253 (2007).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Doherty, D.G. Antigen-specific immune tolerance in the liver. Nat Biomed Eng 3, 763–765 (2019). https://doi.org/10.1038/s41551-019-0445-9
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41551-019-0445-9
This article is cited by
-
Cellular senescence in the cholangiopathies: a driver of immunopathology and a novel therapeutic target
Seminars in Immunopathology (2022)