β-catenin regulates cell–cell adhesion and maintains stemness through Wnt signalling, but how these functions are mechanistically related is not fully understood. A study now identifies CRAD as the mechanistic link, providing insight into how dysregulation of epithelial adhesion contributes to Wnt-driven tumorigenesis.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Cancer Genome Atlas Network. Nature 487, 330–337 (2012).
Korinek, V. et al. Science 275, 1784–1787 (1997).
Nelson, W. J. Biochem. Soc. Trans. 36, 149–55 (2008).
Nelson, W. J. & Nusse, R. Science 303, 1483–1487 (2004).
Ciriello, G. et al. Cell 163, 506–519 (2015).
Hansford, S. et al. JAMA Oncol. 1, 23–32 (2015).
Jung, W. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-018-0215-z (2018).
Edwards, M. et al. Nat. Rev. Mol. Cell Biol. 15, 677 (2014).
Heuberger, J. & Birchmeier, W. Cold Spring Harb. Perspec. Biol. 2, a002915 (2010).
Hülsken, J., Birchmeier, W. & Behrens, J. J. Cell Biol. 127, 2061–2069 (1994).
Orsulic, S. et al. J. Cell Sci. 112, 1237–1245 (1999).
Huels, D. J. et al. EMBO J. 34, 2321–2333 (2015).
Beyaz, S. et al. Nature 531, 53–58 (2016).
Vermeulen, L. et al. Nat. Cell Biol. 12, 468–478 (2010).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing interests.
Rights and permissions
About this article
Cite this article
Eng, G., Braverman, J. & Yilmaz, Ö.H. CRAD as a cytoskeletal tumour suppressor. Nat Cell Biol 20, 1232–1233 (2018). https://doi.org/10.1038/s41556-018-0225-x
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41556-018-0225-x