Epigenetic barriers need to be surmounted in order to increase the efficiency of cardiac reprogramming. A new study now reports that the histone reader PHF7 enhances cardiac reprogramming via recruiting the chromatin remodelling SWI/SNF complex and key transcription factors to the cardiac super enhancers.
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References
Garry, G. A. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-021-00668-z (2021).
Ieda, M. et al. Cell 142, 375–386 (2010).
Soler-Botija, C., Forcales, S. V. & Bayés Genís, A. Semin. Cell Dev. Biol. 97, 26–37 (2020).
Zhou, H. et al. Genes Dev. 31, 1770–1783 (2017).
Yang, S. Y., Baxter, E. M. & Van Doren, M. Dev. Cell 22, 1041–1051 (2012).
Wang, X. et al. Development 146, dev175547 (2019).
Srivastava, D. & DeWitt, N. Cell 166, 1386–1396 (2016).
Qin, H., Zhao, A. & Fu, X. Cell. Mol. Life Sci. 74, 3553–3575 (2017).
Godwin, J. BioEssays 36, 861–871 (2014).
Murry, C. E. & MacLellan, W. R. Science 367, 854–855 (2020).
Scott Thies, R. & Murry, C. E. Development 142, 3077–3084 (2015).
Liu, Y.-W. et al. Nat. Biotechnol. 36, 597–605 (2018).
Büning, H. & Srivastava, A. Mol. Ther. Methods Clin. Dev. 12, 248–265 (2019).
Zangi, L. et al. Nat. Biotechnol. 31, 898–907 (2013).
Chien, K. R. et al. Nat. Biotechnol. 37, 232–237 (2019).
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Eroglu, E., Schell, J.P. & Chien, K.R. PHF7 directs cardiac reprogramming. Nat Cell Biol 23, 440–442 (2021). https://doi.org/10.1038/s41556-021-00684-z
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DOI: https://doi.org/10.1038/s41556-021-00684-z