A form of programmed cell death, necroptosis, in intestinal epithelial cells initiates mucosal inflammation. A study now finds that prostanoid EP4 receptor signalling interferes with RIPK1–RIPK3-dependent MLKL activation, thereby inhibiting necroptosis and accelerating resolution of inflammation.
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Kaneider, N.C., Kaser, A. Prostanoids put a brake on necroptosis in IBD. Nat Cell Biol 23, 680–681 (2021). https://doi.org/10.1038/s41556-021-00717-7
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DOI: https://doi.org/10.1038/s41556-021-00717-7