Neuronal mitochondria perturbation elicits a mitochondrial unfolded protein response (UPRmt) in peripheral tissues cell non-autonomously, dependent on the Wnt signalling pathway. A study now reveals that a Wnt-mediated increase in maternally inherited mitochondria DNA is responsible for transgenerational UPRmt induced by neuronal mitochondria perturbation.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Change history
16 September 2021
A Correction to this paper has been published: https://doi.org/10.1038/s41556-021-00757-z
References
Baugh, L. R. & Day, T. eLife 9, e58498 (2020).
Perez, M. F. & Lehner, B. Nat. Cell Biol. 21, 143–151 (2019).
Moore, R. S., Kaletsky, R. & Murphy, C. T. Cell 177, 1827–1841.e2 (2019).
Klosin, A., Casas, E., Hidalgo-Carcedo, C., Vavouri, T. & Lehner, B. Science 356, 320–323 (2017).
Zhang, Q. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-021-00724-8 (2021).
Shpilka, T. & Haynes, C. M. Nat. Rev. Mol. Cell Biol. 19, 109–120 (2018).
Berendzen, K. M. et al. Cell 166, 1553–1563.e10 (2016).
Zhang, Q. et al. Cell 174, 870–883.e17 (2018).
Gitschlag, B. L. et al. Cell Metab. 24, 91–103 (2016).
Lin, Y. F. et al. Nature 533, 416–419 (2016).
Nargund, A. M., Pellegrino, M. W., Fiorese, C. J., Baker, B. M. & Haynes, C. M. Science 337, 587–590 (2012).
Lee, S. S. et al. Nat. Genet. 33, 40–48 (2003).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing interests.
Rights and permissions
About this article
Cite this article
Park, M., Wang, M.C. Mitochondrial UPR through generations. Nat Cell Biol 23, 820–821 (2021). https://doi.org/10.1038/s41556-021-00729-3
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41556-021-00729-3