Rhythmic removal of circadian clock proteins is important for the strength and periodicity of the circadian rhythm. A study now reveals that chaperone-mediated autophagy regulates the degradation of circadian proteins, and is also transcriptionally regulated by the circadian machinery. This feedback loop helps to maintain circadian oscillations.
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He, C. Chaperone-mediated autophagy on the clock. Nat Cell Biol 23, 1220–1221 (2021). https://doi.org/10.1038/s41556-021-00811-w
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DOI: https://doi.org/10.1038/s41556-021-00811-w