A nanosensor probe that combines a tumour-targeting peptide, a diagnostic reporter and an imaging contrast agent enables early diagnosis, precision imaging, disease stratification and downstream therapeutic response monitoring of metastatic cancer.
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References
Ofori, L. O. et al. ACS Chem. Biol. 10, 1977–1988 (2015).
Widen, J. C. et al. Nat. Biomed. Eng. 5, 264–277 (2021).
Hunt, J. F., Rath, P., Rothschild, K. J. & Engelman, D. M. Biochemistry 36, 15177–15192 (1997).
Weerakkody, D. et al. Proc. Natl Acad. Sci. USA 110, 5834–5839 (2013).
Hao, L. et al. Nat. Mater. https://doi.org/10.1038/s41563-021-01042-y (2021).
Buss, C. G., Dudani, J. S., Akana, R. T. K., Fleming, H. E. & Bhatia, S. N. EBioMedicine 38, 248–256 (2018).
Dudani, J. S., Ibrahim, M., Kirkpatrick, J., Warren, A. D. & Bhatia, S. N. Proc. Natl Acad. Sci. USA 115, 8954–8959 (2018).
Kirkpatrick, J. D. et al. Sci. Transl. Med. 12, eaaw0262 (2020).
Kwong, G. A. et al. Nat. Biotechnol. 31, 63–70 (2013).
Warren, A. D. et al. J. Am. Chem. Soc. 136, 13709–13714 (2014).
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M.B. is a founder and consultant for Akrotome Imaging Inc. and is a consultant at Vergent Bioscience. Both companies are developing optical contrast agents that target lysosomal cysteine protease for imaging tumours during surgery.
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Bogyo, M. A ‘Swiss army knife’ probe for metastatic cancers. Nat. Mater. 20, 1312–1314 (2021). https://doi.org/10.1038/s41563-021-01105-0
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DOI: https://doi.org/10.1038/s41563-021-01105-0