Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Bacterial evolution

Emergence of persistent tubercle bacilli

Experimental evolution of persistence during Mycobacterium canettii infections of mice sheds light on the origins of virulence in ancestral Mycobacterium tuberculosis.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Experimental evolution of a persistent tubercle bacillus.

References

  1. Dubos, R. J. Louis Pasteur: Free Lance of Science 281–282 (Da Capo Press, 1986).

  2. Allen, A. et al. Nat. Microbiol. https://doi.org/10.1038/s41564-021-00938-4 (2021).

  3. Supply, P. & Brosch, R. in Strain Variation in the Mycobacterium tuberculosis Complex: Its Role in Biology, Epidemiology and Control Vol. 1,019 (ed. Gagneux, S.) 27–41 (Springer, 2017).

  4. Brites, D. et al. Front. Microbiol. 9, 2820 (2018).

    Article  Google Scholar 

  5. Supply, P. et al. Nat. Genet. 45, 172–179 (2013).

    Article  CAS  Google Scholar 

  6. Bryant, J. M. et al. Science 372, 6541 (2021).

    Article  Google Scholar 

  7. Ramos, L. et al. Tuberculosis 106, 91–98 (2017).

    Article  CAS  Google Scholar 

  8. Dannenberg, A. M. Pathogenesis of Human Pulmonary Tuberculosis: Insights from the Rabbit Model Ch. 12, 215–229 (ASM Press, 2006).

  9. Ruhl, C. R. et al. Cell 181, 293–305 (2020).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Marcel A. Behr.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Veyrier, F.J., Behr, M.A. Emergence of persistent tubercle bacilli. Nat Microbiol 6, 977–978 (2021). https://doi.org/10.1038/s41564-021-00945-5

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41564-021-00945-5

Search

Quick links

Nature Briefing Microbiology

Sign up for the Nature Briefing: Microbiology newsletter — what matters in microbiology research, free to your inbox weekly.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing: Microbiology