Abstract
Understanding how life on Earth might have originated is the major goal of origins of life chemistry. To proceed from simple feedstock molecules and energy sources to a living system requires extensive synthesis and coordinated assembly to occur over numerous steps, which are governed only by environmental factors and inherent chemical reactivity. Demonstrating such a process in the laboratory would show how life can start from the inanimate. If the starting materials were irrefutably primordial and the end result happened to bear an uncanny resemblance to extant biology — for what turned out to be purely chemical reasons, albeit elegantly subtle ones — then it could be a recapitulation of the way that natural life originated. We are not yet close to achieving this end, but recent results suggest that we may have nearly finished the first phase: the beginning.
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References
Sutherland, J. D. The origin of life — out of the blue. Angew. Chem. Int. Ed. 55, 104–121 (2016).
Weiss, M. C. et al. The physiology and habitat of the last universal common ancestor. Nat. Microbiol. 1, 16116 (2016).
Sleep, N. H. & Zahnle, K. Refugia from asteroid impacts on early Mars and the early Earth. J. Geophys. Res. 103, 28529–28544 (1998).
Abramov, O. & Mojzsis, S. J. Microbial habitability of the Hadean Earth during the late heavy bombardment. Nature 459, 419–422 (2009).
Gánti, T. The Principles of Life (Oxford Univ. Press, 2003).
Paterson, T. & Wood, H. C. S. Deuterium exchange of C-methyl protons in 6,7-dimethyl-8-d-ribityl-lumazine, and studies of the mechanism of riboflavin biosynthesis. J. Chem. Soc. D 290–291 (1969).
Powner, M. W. & Sutherland, J. D. Prebiotic chemistry: a new modus operandi. Phil. Trans. R. Soc. B 366, 2870–2877 (2011).
Miller, S. L. A production of amino acids under possible primitive Earth conditions. Science 117, 528–529 (1953).
Parker, E. T. et al. Primordial synthesis of amines and amino acids in a 1958 Miller H2S-rich spark discharge experiment. Proc. Natl Acad. Sci. USA 108, 5526–5531 (2011).
Sanchez, R. A., Ferris, J. P. & Orgel, L. E. Studies in prebiotic synthesis II. Synthesis of purine precursors and amino acids from aqueous hydrogen cyanide. J. Mol. Biol. 80, 223–253 (1967).
Ritson, D. & Sutherland, J. D. Prebiotic synthesis of simple sugars by photoredox systems chemistry. Nat. Chem. 4, 895–899 (2012).
Ritson, D. J. & Sutherland, J. D. Synthesis of aldehydic ribonucleotide and amino acid precursors by photoredox chemistry. Angew. Chem. Int. Ed. 52, 5845–5847 (2013).
Sauer, M. C., Crowell, R. A. & Shkrob, I. A. Electron photodetachment from aqueous anions. 1. Quantum yields for generation of hydrated electron by 193 and 248 nm laser photoexcitation of miscellaneous inorganic anions. J. Phys. Chem. A 108, 5490–5502 (2004).
Zard, S. Z. Iminyl radicals: a fresh look at a forgotten species (and some of its relatives). Synlett 1996, 1148–1154 (1996).
Lohrmann, R. &. Orgel, L. E. Urea-inorganic phosphate mixtures as prebiotic phosphorylating agents. Science 171, 490–494 (1971).
Schoffstall, A. M. Prebiotic phosphorylation of nucleosides in formamide. Orig. Life 7, 399–412 (1976).
Burcar, B. et al. Darwin's warm little pond: a one-pot reaction for prebiotic phosphorylation and the mobilization of phosphate from minerals in a urea-based solvent. Angew. Chem. Int. Ed. 55, 13249–13253 (2016).
Patel, B. H., Percivalle, C., Ritson, D. J., Duffy, C. D. & Sutherland, J. D. Common origins of RNA, protein and lipid precursors in a cyanosulfidic protometabolism. Nat. Chem. 7, 301–307 (2015).
Jackson, J. B. Natural pH gradients in hydrothermal alkali vents were unlikely to have played a role in the origin of life. J. Mol. Evol. 83, 1–11 (2016).
Martin, W. F., Sousa, F. L. & Lane, N. Energy at life's origin. Science 344, 1092–1093 (2014).
Springsteen, G. Reaching back to jump forward: recent efforts towards a systems-level hypothesis for an early RNA world. ChemBioChem 16, 1411–1413 (2015).
Sojo, V., Herschy, B., Whicher, A., Camprubí, E. & Lane, N. The origin of life in alkaline hydrothermal vents. Astrobiology 16, 181–197 (2016).
Schenk, G., Duggleby, R. G. & Nixon, P. F. Properties and functions of the thiamin diphosphate dependent enzyme transketolase. Int. J. Biochem. Cell Biol. 30, 1297–1318 (1998).
Chipman, D. M., Duggleby, R. G. & Tittmann, K. Mechanisms of acetohydroxyacid synthases. Curr. Opin. Chem. Biol. 9, 475–481 (2005).
Wong, S. H., Lonhienne, T. G., Winzor, D. J., Schenk, G. & Guddat, L. W. Bacterial and plant ketol-acid reductoisomerases have different mechanisms of induced fit during the catalytic cycle. J. Mol. Biol. 424, 168–179 (2012).
Pirrung, M. C., Holmes, C. P., Horowitz, D. M. & Nunn, D. S. Mechanism and stereochemistry of α,β-dihydroxyacid dehydratase. J. Am. Chem. Soc. 113, 1020–1025 (1991).
Richard, J. P. Acid–base catalysis of the elimination and isomerization reactions of triose phosphates. J. Am. Chem. Soc. 106, 4926–4936 (1984).
Pascal, R., Pross, A. & Sutherland, J. D. Towards an evolutionary theory of the origin of life based on kinetics and thermodynamics. Open Biol. 3, 130156 (2013).
Kuhn, H. Model consideration for the origin of life. Naturwissenschaften 63, 68–80 (1976).
Jiménez, J. I., Xulvi-Brunet, R., Campbell, G. W., Turk-MacLeod, R. & Chen, I. A. Comprehensive experimental fitness landscape and evolutionary network for small RNA. Proc. Natl Acad. Sci. USA 110, 14984–14989 (2013).
Engelhart, A. E., Powner, M. W. & Szostak, J. W. Functional RNAs exhibit tolerance for non-heritable 2′–5′ versus 3′–5′ backbone heterogeneity. Nat. Chem. 5, 390–394 (2013).
Bowler, F. R. et al. Prebiotically plausible oligoribonucleotide ligation facilitated by chemoselective acetylation. Nat. Chem. 5, 383–389 (2013).
Boekhoven, J., Hendriksen, W. E., Koper, G. J., Eelkema, R. & van Esch, J. H. Transient assembly of active materials fueled by a chemical reaction. Science 349, 1075–1079 (2015).
Usher, D. A. & McHale, A. H. Hydrolytic stability of helical RNA: a selective advantage for the natural 3′,5′-bond. Proc. Natl Acad. Sci. USA 73, 1149–1153 (1976).
Usher, D. A. Early chemical evolution of nucleic acids: a theoretical model. Science 196, 311–313 (1977).
Rohatgi, R., Bartel, D. P. & Szostak, J. W. Nonenzymatic, template-directed ligation of oligoribonucleotides is highly regioselective for the formation of 3′–5′ phosphodiester bonds. J. Am. Chem. Soc. 118, 3340–3344 (1996).
Kuusela, S. & Lönnberg, H. Metal ion-promoted hydrolysis of uridine 2′,3′-cyclic monophosphate: effect of metal chelates and uncomplexed aquo ions. J. Phys. Org. Chem. 5, 803–811 (1992).
Lehman, N. A recombination-based model for the origin and early evolution of genetic information. Chem. Biodivers. 5, 1707–1717 (2008).
Pace, N. R. Origin of life-facing up to the physical setting. Cell 65, 531–533 (1991).
Acknowledgements
This work was supported by the Medical Research Council (No. MC_UP_A024_1009), and a grant from the Simons Foundation (No. 290362 to J.D.S.). J.D.S. thanks members of his group for helpful discussions and suggestions.
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Sutherland, J. Opinion: Studies on the origin of life — the end of the beginning. Nat Rev Chem 1, 0012 (2017). https://doi.org/10.1038/s41570-016-0012
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DOI: https://doi.org/10.1038/s41570-016-0012
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