In 2019, we published a Review on the relevance of gut microbial metabolites in obesity, non-alcoholic fatty liver disease and type 2 diabetes mellitus. Here, we highlight the importance of the balance between colonic proteolytic and saccharolytic metabolite production for metabolic health and the need to focus on more subgroup-based or personalized nutritional approaches.
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References
Canfora, E. E., Jocken, J. W. & Blaak, E. E. Short-chain fatty acids in control of body weight and insulin sensitivity. Nat. Rev. Endocrinol. 11, 577–591 (2015).
Canfora, E. E., Meex, R. C. R., Venema, K. & Blaak, E. E. Gut microbial metabolites in obesity, NAFLD and T2DM. Nat. Rev. Endocrinol. 15, 261–273 (2019).
van der Beek, C. M. et al. Distal, not proximal, colonic acetate infusions promote fat oxidation and improve metabolic markers in overweight/obese men. Clin. Sci. 130, 2073–2082 (2016).
Liu, Y. et al. Gut microbiome fermentation determines the efficacy of exercise for diabetes prevention. Cell Metab. 31, 77–91 (2020).
Koh, A. et al. Microbially produced imidazole propionate impairs insulin signaling through mTORC1. Cell 175, 947–961 (2018).
Blaak, E. E. Current metabolic perspective on malnutrition in obesity: towards more subgroup-based nutritional approaches? Proc. Nutr. Soc. https://doi.org/10.1017/S0029665120000117 (2020).
Hjorth, M. F. et al. Prevotella-to-Bacteroides ratio predicts body weight and fat loss success on 24-week diets varying in macronutrient composition and dietary fiber: results from a post-hoc analysis. Int. J. Obesity 43, 149–157 (2019).
Zeevi, D. et al. Personalized nutrition by prediction of glycemic responses. Cell 163, 1079–1094 (2015).
Berry, S. E. et al. Human postprandial responses to food and potential for precision nutrition. Nat. Med. 26, 964–973 (2020).
Müller, M. et al. Distal colonic transit is linked to gut microbiota diversity and microbial fermentation in humans with slow colonic transit. Am. J. Physiol. Gastrointest. Liver Physiol. 318, G361–G369 (2020).
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The authors kindly congratulate Nature Reviews Endocrinology for their 15th anniversary! For the future, we wish that the journal team keeps up their excellent editorial service and continues to fulfil their goals to maximize the usefulness and impact of each article at the forefront of research in the broad field of endocrinology.
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Canfora, E.E., Blaak, E.E. Towards personalized microbial substrates for metabolic health. Nat Rev Endocrinol 16, 613–614 (2020). https://doi.org/10.1038/s41574-020-00416-7
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DOI: https://doi.org/10.1038/s41574-020-00416-7
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