A recent article from Science Translational Medicine demonstrated the importance of pancreas-derived mesenchymal stem cells (PMSCs) for rejuvenating the exocrine pancreas in two mouse models of type 1 diabetes mellitus. PMSCs boosted levels of IL-6 in T helper 1 and T helper 17 cells, which transiently triggered IFNγ and TNF expression and curtailed IL-17 expression to shelter β-cells from immune-mediated damage.
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References
Kou, X. et al. Exocrine pancreas regeneration modifies original pancreas to alleviate diabetes in mouse models. Sci. Transl Med. 14, eabg9170 (2022).
Cho, J., D’Antuono, M., Glicksman, M., Wang, J. & Jonklaas, J. A review of clinical trials: mesenchymal stem cell transplant therapy in type 1 and type 2 diabetes mellitus. Am. J. Stem. Cells 7, 82–93 (2018).
Shapiro, A. M., Pokrywczynska, M. & Ricordi, C. Clinical pancreatic islet transplantation. Nat. Rev. Endocrinol. 13, 268–277 (2017).
Khatri, R., Petry, S. F. & Linn, T. Intrapancreatic MSC transplantation facilitates pancreatic islet regeneration. Stem Cell Res. Ther. 12, 121 (2021).
Suk, K. et al. IFN-gamma/TNF-alpha synergism as the final effector in autoimmune diabetes: a key role for STAT1/IFN regulatory factor-1 pathway in pancreatic beta cell death. J. Immunol. 166, 4481–4489 (2001).
Hunter, C. A. & Jones, S. A. IL-6 as a keystone cytokine in health and disease. Nat. Immunol. 16, 448–457 (2015).
Rajendran, S. et al. IL-6 is present in beta and alpha cells in human pancreatic islets: Expression is reduced in subjects with type 1 diabetes. Clin. Immunol. 211, 108320 (2020).
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Khatri, R., Linn, T. Pancreatic mesenchymal stem cells might protect β-cells. Nat Rev Endocrinol 18, 725–726 (2022). https://doi.org/10.1038/s41574-022-00763-7
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DOI: https://doi.org/10.1038/s41574-022-00763-7