Over the past decade, many studies have revealed the importance of the gut microbiome in disease development and treatment, including in cancer. Because both host genetics and the gut microbiome can influence host phenotype and treatment outcome, there is an urgent need to develop precision medicine and personalize dietary supplementation based on an individual’s microbiome.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Dysregulated bile acid receptor-mediated signaling and IL-17A induction are implicated in diet-associated hepatic health and cognitive function
Biomarker Research Open Access 06 November 2020
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 /Â 30Â days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Singh, V. et al. Dysregulated microbial fermentation of soluble fiber induces cholestatic liver cancer. Cell 175, 679–694 (2018).
Koh, A. et al. From dietary fiber to host physiology: short-chain fatty acids as key bacterial metabolites. Cell 165, 1332–1345 (2016).
Weitkunat, K. et al. Short-chain fatty acids and inulin, but not guar gum, prevent diet-induced obesity and insulin resistance through differential mechanisms in mice. Sci. Rep. 7, 6109 (2017).
Sivan, A. et al. Commensal Bifidobacterium promotes antitumor immunity and facilitates anti-PD-L1 efficacy. Science 350, 1084–1089 (2015).
Chiang, J. Y. L. & Ferrell, J. M. Bile acid metabolism in liver pathobiology. Gene Expr. 18, 71–87 (2018).
Jena, P. K. et al. Western diet-induced dysbiosis in farnesoid X receptor knockout mice causes persistent hepatic inflammation after antibiotic treatment. Am. J. Pathol. 187, 1800–1813 (2017).
Sheng, L. et al. Hepatic inflammation caused by dysregulated bile acid synthesis is reversible by butyrate supplementation. J. Pathol. 243, 431–441 (2017).
Belcheva, A. et al. Gut microbial metabolism drives transformation of MSH2-deficient colon epithelial cells. Cell 158, 288–299 (2014).
Tsilimigras, D. I. et al. Histone deacetylase inhibitors in hepatocellular carcinoma: a therapeutic perspective. Surg. Oncol. 27, 611–618 (2018).
Sheng, L. et al. Gender differences in bile acids and microbiota in relationship with gender dissimilarity in steatosis induced by diet and FXR inactivation. Sci. Rep. 7, 1748 (2017).
Acknowledgements
Y.Y.W. is Professor and Vice Chair for Research in Department of Pathology & Laboratory Medicine at University of California, Davis. This work is supported by grants CA222490 and CA179582 from NCI, NIH. The authors thank Lili Sheng and Julia Ann Wu for their contributions in preparing this manuscript.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing interests.
Rights and permissions
About this article
Cite this article
Wan, YJ.Y., Jena, P.K. Precision dietary supplementation based on personal gut microbiota. Nat Rev Gastroenterol Hepatol 16, 204–206 (2019). https://doi.org/10.1038/s41575-019-0108-z
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41575-019-0108-z