A new study discovered thousands of expression quantitative trait loci (eQTLs) in the renal glomerular and tubulointerstitial compartments and integrated these data with other omics data sets to identify genes with roles in the pathogenesis of chronic kidney disease. This report reinforces the necessity of using compartment-derived eQTLs to advance kidney genomic discovery.
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The author’s work is supported by the Charles Woodson Clinical Research Fund, the Ravitz Foundation and by National Institutes of Health RO1-DK108805.
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Sampson, M.G. Glomerular and tubulointerstitial eQTLs for genomic discovery. Nat Rev Nephrol 15, 3–4 (2019). https://doi.org/10.1038/s41581-018-0089-0
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DOI: https://doi.org/10.1038/s41581-018-0089-0