Abstract
Mesangial cells are stromal cells that are important for kidney glomerular homeostasis and the glomerular response to injury. A growing body of evidence demonstrates that mesenchymal stromal cells, such as stromal fibroblasts, pericytes and vascular smooth muscle cells, not only specify the architecture of tissues but also regulate developmental processes, vascularization and cell fate specification. In addition, through crosstalk with neighbouring cells and indirectly through the remodelling of the matrix, stromal cells can regulate a variety of processes such as immunity, inflammation, regeneration and in the context of maladaptive responses — fibrosis. Insights into the molecular phenotype of kidney mesangial cells suggest that they are a specialized stromal cell of the glomerulus. Here, we review our current understanding of mesenchymal stromal cells and discuss how it informs the function of mesangial cells and their role in disease. These new insights could lead to a better understanding of kidney disease pathogenesis and the development of new therapies for chronic kidney disease.
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Acknowledgements
We wish to dedicate this Perspective to the memory of D. Schlondorff who kept the memory of mesangial cells alive during the era of the podocyte. We also thank E. Unanue (Washington University in St Louis, MO, USA), J. Schraibman (Washington University in St Louis, MO, USA), and J. C. Marler (St Louis University, MO, USA) for investigating the origin of the word mesangium, and R. Kopan (Cincinnati Children’s Hospital Medical Center, OH, USA) for helpful discussions. This work was supported by Genentech.
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S.A., B.K., L.O., and A.S.S. researched data for the article and reviewed and/or edited the manuscript before submission. All authors contributed substantially to discussion of the content and contributed to writing the article.
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S.A., B.K. and A.S.S. are employees of Genentech Research and Early Development. J.-J.C. is an employee of Pin Pharmaceuticals. L.O. declares no competing interests.
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Avraham, S., Korin, B., Chung, JJ. et al. The Mesangial cell — the glomerular stromal cell. Nat Rev Nephrol 17, 855–864 (2021). https://doi.org/10.1038/s41581-021-00474-8
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DOI: https://doi.org/10.1038/s41581-021-00474-8
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