A prospective observational study investigated whether two interferon-stimulated gene expression scores could predict progression to autoimmune connective tissue disease in at-risk individuals (antinuclear antibody-positive). Of 118 patients, 19 progressed to disease. Both interferon scores were increased in these at-risk individuals who went on to develop disease. Patients who progressed to disease did not have different baseline clinical characteristics or ultrasonography findings compared with patients who did not progress to disease. These interferon scores may enable early intervention for disease prevention.
References
Original article
Md Yusof, M. Y. et al. Prediction of autoimmune connective tissue disease in an at-risk cohort: prognostic value of a novel two-score system for interferon status. Ann. Rheum. Dis. https://doi.org/10.1136/annrheumdis-2018-213386 (2018)
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Leake, I. Predicting progression to disease in an at-risk cohort. Nat Rev Rheumatol 14, 442 (2018). https://doi.org/10.1038/s41584-018-0050-4
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41584-018-0050-4