Negative results of yet another IL-1 inhibitor in the treatment of knee osteoarthritis add to a pool of data indicating that this strategy does not reduce pain or inflammation and is thereby a dead end. Should we therefore shelve further plans to test or use this therapeutic strategy?
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References
Fleischmann, R. M. et al. A phase 2 trial of lutikizumab, an anti-interleukin 1α/β dual variable domain immunoglobulin, in knee osteoarthritis patients with synovitis. Arthritis Rheumatol. https://doi.org/10.1002/art.40840 (2019).
Chevalier, X. et al. Intraarticular injection of anakinra in osteoarthritis of the knee: a multicenter, randomized, double-blind, placebo-controlled study. Arthritis Rheum. 61, 344–352 (2009).
Cohen, S. et al. A randomized, double-blind study of AMG 108 (a fully human monoclonal antibody to IL-1R1) in patients with osteoarthritis of the knee. Arthritis. Res. Ther. 13, R125 (2011).
Kapoor, M. et al. Role of pro inflammmatory cytokines in the pathophysiology of osteoarthritis. Nat. Rev. Rheumatol. 7, 33–42 (2011).
Bougault, C. et al. Stress-induced cartilage degradation does not depend on the NLRP3 inflammasome in human osteoarthritis and mouse models. Arthritis. Rheum. 64, 3972–3981 (2012).
van Dalen, S. C. et al. Interleukin-1 is not involved in synovial inflammation and cartilage destruction in collagenase-induced osteoarthritis. Osteoarthr. Cartil. 25, 385–396 (2017).
Clements, K. M. et al. Gene deletion of interleukin-1β, interleukin-1β-converting enzyme, inducible nitric oxide synthase, or stromelysin 1 accelerates the development of knee osteoarthritis in mice after surgical transection of the medial collateral ligament and partial medial menisectomy. Arthritis Rheum. 48, 3352–3363 (2003).
Richette, P. et al. A high interleukin 1 receptor antagonist/IL-1β ratio occurs naturally in knee osteoarthritis. J. Rheumatol. 35, 1650–1654 (2008).
Kraus, V. B. et al. Effects of intra-articular IL1-Ra for acute anterior cruciate ligament knee injury: a randomized controlled pilot trial (NCT00332254). Osteoarthr. Cartil. 20, 271–278 (2012).
Schieker, M. et al. Interleukin-1β inhibition with canakinumab associates with reduced rates of total hip and knee replacement (THR/TKR) and osteoarthritis (OA) symptoms: exploratory results from the Canakinumab Anti-Inflammatory Thrombosis Outcomes Study (CANTOS) [abstract]. Arthritis Rheumatol. 70 (Suppl. 10), 445 (2018).
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Chevalier, X., Eymard, F. Anti-IL-1 for the treatment of OA: dead or alive?. Nat Rev Rheumatol 15, 191–192 (2019). https://doi.org/10.1038/s41584-019-0185-y
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DOI: https://doi.org/10.1038/s41584-019-0185-y
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