Recent patents relating to epigenomic analyses, modification and engineering.
Patent number | Description | Assignee | Inventor | Date |
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US 11,286,468 | Engineered CRISPR–Cas9 nucleases with altered and improved protospacer adjacent motif (PAM) specificities and their use in genomic engineering, epigenomic engineering, and genome targeting. | General Hospital Corp. (Boston, MA, USA) | Joung JK, Kleinstiver B | 3/29/2022 |
US 11,168,313 | Engineered CRISPR from Prevotella and Francisella 1 (Cpf1) nucleases with altered and improved target specificity and their use in genomic engineering, epigenomic engineering, genome targeting, genome editing, and in vitro diagnostics. | General Hospital Corp. (Boston, MA, USA) | Joung JK, Kleinstiver B | 11/9/2021 |
US 11,072,782 | A construct for epigenomic modification of genes composed of a Kruppel-associated box zinc finger protein or homologous; a DNA region capable of binding to the target gene or homologous; a human DNA methyltransferase DNMT3A or homologous and a murine DNA methyltransferase DNMT3L or homologous, wherein the components are linked to each other either directly or via at least one linker. The construct is a designer epigenome modifier that can be used to silence genes coding for a protein in leukocytes that avoids the internalization of human immunodeficiency viruses in immune cells. | Albert Ludwig University of Freiburg (Freiburg, Germany) | Cathomen T, Mussolino C, Cornu TI, Mlambo T, Nitsch S, Alzubi J, Romito M | 7/27/2021 |
US 11,060,078 | Engineered CRISPR–Cas9 nucleases with improved specificity and their use in genomic engineering, epigenomic engineering, genome targeting, and genome editing. | General Hospital Corp. (Boston, MA, USA) | Joung JK, Kleinstiver B, Pattanayak V | 7/13/2021 |
US 10,676,735 | Methods of using CRISPR–Cas9-based epigenomic editing systems for high-throughput screening of regulatory element function. | Duke University (Durham, NC, USA) | Gersbach CA, Crawford GE, Reddy TE, Klann TS | 6/9/2020 |
US 10,329,614 | Methods for DNA sequencing and performing epigenomic analyses, including immobilizing a plurality of copies of a DNA molecule on a surface, stretching at least a portion of the immobilized DNA molecules, and sequencing at least a portion of the immobilized, stretched DNA molecules. | STC.UNM (Albuquerque, NM, USA) | Edwards JS | 6/25/2019 |
US 9,023,819 | A method for treating a subject having or suspected of having a disease or condition associated with aberrant hypomethylation of one or more genes in the subject, involving a tailored epigenomic modification of the subject using methylated polynucleotides directed to hypomethylated genes in the subject. Also, a medicinal composition for treating a subject having or suspected of having a disease or condition associated with aberrant hypomethylation of one or more genes in the subject, including methylated polynucleotides directed to hypomethylated genes in the subject, so as to result in a tailored epigenomic modification of the subject upon administration. | National Chung Cheng University (Chia-Yi, Taiwan) | Leu Y-W, Hsiao S-H, Huang TH-M | 5/5/2015 |
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Epigenomics. Nat Biotechnol 40, 1181 (2022). https://doi.org/10.1038/s41587-022-01433-9
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DOI: https://doi.org/10.1038/s41587-022-01433-9