The function of transposable elements present in mammalian genomes remains an enigma. In this issue, Bodega, Abrignani and colleagues show that LINE1-containing transcripts are key regulators of T cell effector function and exhaustion.
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Lusic, M., Mhlanga, M.M. Walking the LINEs hidden in the dark matter of the genome. Nat Genet 54, 98–99 (2022). https://doi.org/10.1038/s41588-021-01003-w
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DOI: https://doi.org/10.1038/s41588-021-01003-w