Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Cancer evolution

A medley of resistance in ovarian cancers

Multi-omic profiling of lesions at autopsy reveals a plethora of resistance mechanisms present within individual patients with ovarian cancer. This highlights the extreme challenge faced in treating end-stage disease and underscores the need for new methods of early detection and intervention.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Multi-omic characterization of resistance mechanisms.

References

  1. Iacobuzio-Donahue, C. A. et al. Nat. Rev. Cancer 19, 686–697 (2019).

    Article  CAS  PubMed  Google Scholar 

  2. Burdet, N. L. et al. Nat. Genet. https://doi.org/10.1038/s41588-023-01320-2 (2023).

  3. Rose, P. G., Piver, M. S., Tsukada, Y. & Lau, T. S. Cancer 64, 1508–1513 (1989).

    Article  CAS  PubMed  Google Scholar 

  4. Güth, U. et al. Cancer 110, 1272–1280 (2007).

    Article  PubMed  Google Scholar 

  5. Nguyen, L., Martens, J. W. M., Van Hoeck, A. & Cuppen, E. Nat. Commun. 11, 5584 (2020).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Geoff Macintyre.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Hernando, B., Macintyre, G. A medley of resistance in ovarian cancers. Nat Genet 55, 361–362 (2023). https://doi.org/10.1038/s41588-023-01303-3

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41588-023-01303-3

Search

Quick links

Nature Briefing: Cancer

Sign up for the Nature Briefing: Cancer newsletter — what matters in cancer research, free to your inbox weekly.

Get what matters in cancer research, free to your inbox weekly. Sign up for Nature Briefing: Cancer