Photorhabdus noenieputensis (a gut microbiota symbiont of nematodes) produces a macrocyclic antibiotic, evybactin, that selectively kills Mycobacterium tuberculosis (Mtb). The Mtb membrane transporter BacA imports evybactin into the cell, where it binds to DNA gyrase and causes cell death.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Kinsella, R. L. et al. Perspectives and advances in the understanding of tuberculosis. Annu. Rev. Pathol. 16, 377–408 (2021). This is a Review of tuberculosis.
Lewis, K. The science of antibiotic discovery. Cell 181, 29–45 (2020). This Perspective describes the state of the art in the field and the promising approaches to antibiotic discovery.
Imai, Y. et al. A new antibiotic selectively kills Gram-negative pathogens. Nature 576, 459–464 (2019). This paper describes the rationale for using Photorhabdus species to discover drug-like compounds.
Gavrish, E. et al. Lassomycin, a Ribosomally Synthesized Cyclic Peptide, Kills Mycobacterium tuberculosis by Targeting the ATP-Dependent Protease ClpC1P1P2. Chem. Biol. 21, 509–518 (2014). This paper reports the discovery of a selective compound that targets the Clp protease.
Quigley, J. et al. Novel antimicrobials from uncultured bacteria acting against Mycobacterium tuberculosis. mBio 11, 4 (2020). This paper reports the discovery of amycobactin, which selectively targets mycobacteria.
Additional information
Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
This is a summary of: Imai, Y. et al. Evybactin is a DNA gyrase inhibitor that selectively kills Mycobacterium tuberculosis. Nat. Chem. Biol. https://doi.org/10.1038/s41589-022-01102-7 (2022).
Rights and permissions
About this article
Cite this article
Selective uptake of a DNA gyrase poison kills Mycobacterium tuberculosis. Nat Chem Biol 18, 1174–1175 (2022). https://doi.org/10.1038/s41589-022-01103-6
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41589-022-01103-6