Biased signaling gives hormones, probes or drugs distinct functional outcomes via the same receptor. The Biased Signaling Atlas (https://BiasedSignalingAtlas.org) provides a community hub with data and tools to advance this paradigm, which may yield safer and more potent drugs.
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Data availability
All data are available in the online Biased Signaling Atlas (https://BiasedSignalingAtlas.org) and GitHub (https://github.com/protwis/gpcrdb_data). Documentation is available at http://docs.biasedsignalingatlas.org.
Code availability
All open-source code can be obtained from GitHub (https://github.com/protwis/protwis) under the permissive Apache 2.0 License (https://www.apache.org/licenses/LICENSE-2.0).
References
Kohout, T. A. et al. J. Biol. Chem. 279, 23214–23222 (2004).
Gomes, I. et al. Proc. Natl Acad. Sci. USA 117, 11820–11828 (2020).
Spengler, D. et al. Nature 365, 170–175 (1993).
Hollenberg, M. D. et al. Br. J. Pharmacol. 171, 1180–1194 (2014).
Schmid, C. L., Raehal, K. M. & Bohn, L. M. Proc. Natl Acad. Sci. USA 105, 1079–1084 (2008).
Dean, T., Vilardaga, J. P., Potts, J. T. Jr & Gardella, T. J. Mol. Endocrinol. 22, 156–166 (2008).
Smith, J. S., Lefkowitz, R. J. & Rajagopal, S. Nat. Rev. Drug Discov. 17, 243–260 (2018).
Kenakin, T. & Christopoulos, A. Nat. Rev. Drug Discov. 12, 205–216 (2013).
Hauser, A. S., Attwood, M. M., Rask-Andersen, M., Schioth, H. B. & Gloriam, D. E. Nat. Rev. Drug Discov. 16, 829–842 (2017).
Foster, S. R. et al. Cell 179, 895–908 e821 (2019).
Kolb, P. et al. Br. J. Pharmacol 179, 3651–3674 (2022).
Anderson, A. et al. Proc. Natl Acad. Sci. USA 117, 14522–14531 (2020).
Avet, C. et al. Elife 11, 2020.2004.2020.052027 (2022).
Ghosh, E. et al. Cell Rep. 28, 3287–3299 e3286 (2019).
Wall, M. J. et al. Nat. Commun. 13, 4150 (2022).
Gillis, A. et al. Sci. Signal. 13, eaaz3140 (2020).
Omieczynski, C. et al. Preprint at bioRxiv https://doi.org/10.1101/742643 (2019).
UniProt, C. Nucleic Acids Res. 49, D480–D489 (2021).
Hauser, A. S. et al. Elife 11, 22 (2022).
Volkow, N. D. & Blanco, C. Mol. Psychiatry 26, 218–233 (2021).
Yang, P. et al. Circulation 135, 1160–1173 (2017).
Ochoa, D. et al. Nucleic Acids Res. 49, D1302–D1310 (2021).
Wojciechowicz, M. L. & Ma'ayan, A. Nat. Rev. Drug Discov. 19, 374 (2020).
Harding, S. D. et al. Nucleic Acids Res. 50, D1282–D1294 (2022).
Acknowledgements
This work was supported by grants from the Lundbeck Foundation (R313-2019-526) and the Novo Nordisk Foundation (NNF18OC0031226) to D.E.G. This article is based upon work from COST Action ERNEST (CA18133), supported by COST (European Cooperation in Science and Technology, www.cost.eu).
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Contributions
Conceptualization, D.E.G.; methodology, A.J.K. and D.E.G.; data curation, A.S.H., E.G., K.H., L.D. and S.G.; validation: A.J.K., D.E.G. and K.H.; writing: original draft, D.E.G.; writing: review and editing, all authors; visualization, D.E.G.; funding acquisition, D.E.G.; software, A.J.K., A.M. and J.C.; supervision, A.J.K., A.S.H, D.E.G. and K.H.
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D.E.G. and A.J.K. have part-time employments at Kvantify. After completing their contribution to this study, A.M. and S.G. moved to Novo Nordisk A/S. The remaining authors declare no competing interests.
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Caroli, J., Mamyrbekov, A., Harpsøe, K. et al. A community Biased Signaling Atlas. Nat Chem Biol 19, 531–535 (2023). https://doi.org/10.1038/s41589-023-01292-8
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DOI: https://doi.org/10.1038/s41589-023-01292-8