Cyclic dinucleotides (CDNs) are potent activators of the innate immune sensor STING. The identification of a CDN importer sheds new light on the regulation of extracellular CDNs.
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A.A. is a shareholder in a company that is developing STING- and cGAS-directed therapeutics.
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Guey, B., Ablasser, A. A carrier for cyclic dinucleotides. Nat Immunol 20, 1418–1420 (2019). https://doi.org/10.1038/s41590-019-0521-z
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DOI: https://doi.org/10.1038/s41590-019-0521-z