CAR T cells are engineered to recognize tumor-specific antigens and kill tumor cells. A study of CAR T cell activation using single-molecule microscopy reveals that CARs fail to efficiently convert antigen binding into early T cell signaling events.
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Lillemeier, B.F. CARs need a jump start to get going. Nat Immunol 21, 823–824 (2020). https://doi.org/10.1038/s41590-020-0735-0
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DOI: https://doi.org/10.1038/s41590-020-0735-0