In patients with rheumatoid arthritis, a short supply of aspartate in the mitochondria can force the endoplasmic reticulum of T cells to generate transmembrane TNF, which in turn contributes to synovial inflammation.
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Scherlinger, M., Tsokos, G.C. Shortage of aspartate in mitochondria fuels arthritis. Nat Immunol 22, 1474–1476 (2021). https://doi.org/10.1038/s41590-021-01069-y
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DOI: https://doi.org/10.1038/s41590-021-01069-y