Enteroviral infection persistence as determined by host genetic susceptibility, rather than independent, short-lived infections, may contribute to islet autoimmunity and be a precursor to the development of type 1 diabetes.
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References
Yoon, J. W., Austin, M., Onodera, T. & Notkins, A. L. N. Engl. J. Med. 300, 1173–1179 (1979).
Skog, O., Klingel, K., Roivainen, M. & Korsgren, O. Diabetologia 62, 1097–1099 (2019).
Vehik, K. et al. Nat. Med. https://doi.org/10.1038/s41591-019-0667-0 (2019).
Dotta, F. et al. Proc. Natl Acad. Sci. USA 104, 5115–5120 (2007).
Krogvold, L. et al. Diabetes 64, 1682–1687 (2015).
Flodstrom, M., Maday, A., Balakrishna, D., Cleary, M. M., Yoshimura, A. & Sarvetnick, N. Nat. Immunol. 3, 373–382 (2002).
Thomas, N. J., Jones, S. E., Weedon, M. N., Shields, B. M., Oram, R. A. & Hattersley, A. T. Lancet Diabetes Endocrinol. 6, 122–129 (2018).
Leete, P. et al. Diabetes 65, 1362–1369 (2016).
Woittiez, N. J. & Roep, B. O. Immunotherapy 7, 163–174 (2015).
Kracht, M. J. et al. Nat. Med. 23, 501–507 (2017).
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Roep, B.O. A viral link for type 1 diabetes. Nat Med 25, 1816–1818 (2019). https://doi.org/10.1038/s41591-019-0689-7
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DOI: https://doi.org/10.1038/s41591-019-0689-7
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