Our light environment can strongly influence our mental health. Kai An and colleagues dissect the neuronal circuit mediating depression-related behaviors induced by mistimed light input in mice, implicating the nucleus accumbens as the downstream target of the neural pathway between intrinsically photosensitive retinal ganglion cells and the perihabenular nucleus.
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References
An, K. et al. Nat. Neurosci. https://doi.org/10.1038/s41593-020-0640-8 (2020).
Lewy, A. J., Lefler, B. J., Emens, J. S. & Bauer, V. K. Proc. Natl Acad. Sci. USA 103, 7414–7419 (2006).
Bedrosian, T. A. & Nelson, R. J. Mol. Psychiatry 18, 751–757 (2013).
Scott, A. J., Monk, T. H. & Brink, L. L. Int. J. Occup. Environ. Health 3(Suppl 2), S2–S9 (1997).
Hansen, B. T., Sønderskhov, K. M., Hageman, I., Dinesen, P. T. & Østergaarde, S. D. Epidemiology 28, 346–353 (2017).
LeGates, T. A., Fernandez, D. C. & Hattar, S. Nat. Rev. Neurosci. 15, 443–454 (2014).
Bedrosian, T. A., Fonken, L. K., Walton, J. C., Haim, A. & Nelson, R. J. Psychoneuroendocrinology 36, 1062–1069 (2011).
Vandewalle, G. et al. Proc. Natl Acad. Sci. USA 107, 19549–19554 (2010).
Fernandez, D. C. et al. Cell 175, 71–84.e18 (2018).
LeGates, T. A. et al. Nature 491, 594–598 (2012).
Hattar, S., Liao, H. W., Takao, M., Berson, D. M. & Yau, K. W. Science 295, 1065–1070 (2002).
Berson, D. M., Dunn, F. A. & Takao, M. Science 295, 1070–1073 (2002).
Schmidt, T. M., Chen, S. K. & Hattar, S. Trends Neurosci. 34, 572–580 (2011).
Stuber, G. D., Britt, J. P. & Bonci, A. Biol. Psychiatry 71, 1061–1067 (2012).
Hanford, N. & Figueiro, M. J. Alzheimers Dis. 33, 913–922 (2013).
Golden, R. N. et al. Am. J. Psychiatry 162, 656–662 (2005).
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LeGates, T.A., Kvarta, M.D. Illuminating a path from light to depression. Nat Neurosci 23, 785–787 (2020). https://doi.org/10.1038/s41593-020-0659-x
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DOI: https://doi.org/10.1038/s41593-020-0659-x